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| 1 |
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Q:
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Ferrobacillus ferrooxidans is an organism that oxidizes Fe2+ in FeS2 to produce sulfuric acid. What is the role of O2 in its metabolism? |
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A
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Electron Source |
B
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Terminal Electron Acceptor |
C
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Catalyst |
D
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Reducing Agent |
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Tags:
Oxidative Phosphorylation | Redox Reactions | |
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| 2 |
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Q:
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Which of the following molecules that participate in the electron transport chain has the lowest affinity for electrons? |
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A
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Oxygen |
B
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NAD+ |
C
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Cytochrome C Oxidase |
D
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Cytochrome C |
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Tags:
Oxidative Phosphorylation | |
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| 3 |
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Q:
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The energy derived from oxidative metabolism in the mitochondria comes in the form of |
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A
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NADPH |
B
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NADH |
C
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ATP |
D
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GTP |
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Tags:
Oxidative Phosphorylation | |
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| 4 |
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Q:
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The F1-ATPase catalyzes the synthesis of ATP from ADP. Which
of the following directly provides the necessary energy to drive
the reaction?
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A
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Movement of H2O |
B
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Movement of H+ |
C
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Breakdown of CO2 |
D
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Formation of H2O |
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Tags:
Oxidative Phosphorylation | |
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| 5 |
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Q:
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ATP can be generated by oxidative phosphorylation in the mitochondria via the electron transport chain, which comprises of a series of hydrogen pumps, electron carriers and ATP synthase. An electrochemical H+ gradient is produced across the inner mitochondrial membrane when H+ is pumped (driven by redox reactions within the proton pump complexes) from the matrix into the intermembrane space. The return of H+ into the matrix through ATP synthase drives the synthesis of ATP. Oligomycin is a macrolide (type of antibiotic) that inhibits the proton channel (F0 subunit) of ATP synthase. What can we expect to happen to the H+ electrochemical gradient with the introduction of oligomyciin? |
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A
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The buildup of H+ in the intermembrane space would eventually overcome oligomycin and ATP would continue to be generated. |
B
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H+ would begin to flow from the intermembrane space into the matrix back through the proton pump complexes of the ETC. |
C
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The H+ gradient would be unaffected. |
D
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H+ would stop being pumped from the matrix into the intermembrane space. |
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Tags:
Oxidative Phosphorylation | Membrane Transport and Signalling | |
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| 6 |
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Q:
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ATP can be generated by oxidative phosphorylation in the mitochondria via the electron transport chain, which comprises of a series of hydrogen pumps, electron carriers and ATP synthase. An electrochemical H+ gradient is produced across the inner mitochondrial membrane when H+ is pumped (driven by redox reactions within the proton pump complexes) from the matrix into the intermembrane space. The return of H+ into the matrix through ATP synthase drives the synthesis of ATP. Oligomycin is a macrolide (type of antibiotic) that inhibits the proton channel (F0 subunit) of ATP synthase. Dinitrophenol (DNP) is a known metabolic poison that uncouples oxidative phosphorylation by carrying protons across the inner mitochondrial membrane from the intermembrane space to the matrix. What is an expected result when both oligomycin and DNP are present in mitochondria? |
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A
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The actions of oligomycin and DNP cancel each other out. There is no net effect on regular oxidative phosphorylatiive ATP generation. ATP is produced as normal. |
B
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ATP is not produced but a lot of heat is generated. |
C
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ATP is generated, but less than normal. |
D
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ATP is not produced and the proton pumps of the ETC stop pumping protons from the matrix to the intermembrane space. |
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Tags:
Oxidative Phosphorylation | Membrane Transport and Signalling | |
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| 7 |
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Q:
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Which is a form of cell death that involves cell shrinkage? |
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A
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apoptosis |
B
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oncosis |
C
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karyorrhexis |
D
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karyolysis |
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Tags:
Oxidative Phosphorylation | |
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| 8 |
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Q:
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In the electron transport chain of aerobic organisms, which molecule is used as the terminal electron acceptor? |
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A
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Cytochrome C |
B
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NADH |
C
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Complex IV |
D
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O2 |
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Tags:
Oxidative Phosphorylation | |
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| 9 |
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Q:
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The MAJOR reason that aerobes cannot live in the absence of oxygen is that |
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A
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The Citric Acid cycle needs to oxidize oxygen in order to complete its reaction |
B
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Glycolysis will not run in the absence of oxygen |
C
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The ETC uses oxygen as its final electron acceptor |
D
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All of the above |
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Tags:
Glycolysis, Gluconeogenesis, PPP | Oxidative Phosphorylation | |
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| 10 |
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Q:
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Acute cyanide poisoning results in the inhibition of the electron transport chain in mitochondria and lactic acidosis. This lethal mechanism is most similar to which of the following? |
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A
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Asphyxiation |
B
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Starvation |
C
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Hemorrhage |
D
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Apoptosis |
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Tags:
Oxidative Phosphorylation | Eukaryotic Cells | |
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| 11 |
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Q:
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What is the source of electrons and what is the terminal electron receptor of the electron transport chain in ADP phosphorylation in mitochondria? |
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A
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water, NADP |
B
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NADH, oxygen |
C
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ADP, NAD |
D
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ADP, oxygen |
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Tags:
Oxidative Phosphorylation | |
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| 12 |
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Q:
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For a mutation that caused pores to open in the inner membrane of the mitochondria, which of the following effects would be seen in the organism? |
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A
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Decreased production of ATP |
B
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Reduced ability to perform the Krebs cycle |
C
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Reduced affinity of pyruvate for Coenzyme A |
D
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Decreased efficiency of the electron transport chain |
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Tags:
Oxidative Phosphorylation | Eukaryotic Cells | |
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| 13 |
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Q:
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Which of the following would NOT support the chemiosmotic-based model of oxidative phosphorylation?
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A
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The transfer of electrons through the electron transport chain results in the formation of a proton gradient across the inner mitochondrial membrane
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B
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Oxidative phosphorylation cannot occur in cells with breached mitochondrial membranes
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C
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Raising the pH of the fluid in the intermembrane space results in ATP synthesis
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D
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The order of the enzyme complexes in the electron transport chain results in proton flow in one direction
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Tags:
Oxidative Phosphorylation | Membrane Transport and Signalling | |
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| 14 |
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Q:
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Which of the following is NOT true regarding the proton-motive force generated by the electron transport chain? |
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A
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The proton-motive force includes a pH gradient component |
B
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The proton-motive force includes an electrical potential gradient component |
C
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The proton-motive force cannot be used for active transport processes |
D
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The proton-motive force is used to synthesize ATP |
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Tags:
Oxidative Phosphorylation | |
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| 17 |
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Q:
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Which of the following is correct about the beta oxidation of fatty acids?
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A
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Occurs in the intermembrane space of the mitochondria
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B
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Produces one molecule each of NADPH and FADH2 in a single round
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C
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Is the same for unsaturated and saturated fatty acids
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D
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Produces two-carbon molecules that then enter the Citric Acid Cycle
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Tags:
Oxidative Phosphorylation | Metabolism of Fatty Acids and Proteins | Citric Acid Cycle | |
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| 18 |
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Q:
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If 18O-labeled O2 were used to track its usage in the human body, in which of the following molecules would the labeled oxygen be most abundant? |
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A
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glucose |
B
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fats |
C
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proteins |
D
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water |
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Tags:
Oxidative Phosphorylation | |
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| 19 |
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Q:
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Mitochondria with proton-permeable inner membranes would exhibit which of the following properties? |
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A
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inefficient ATP production |
B
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inability to perform Krebs cycle |
C
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higher chromosomal mutation rate |
D
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inability to run the electron transport chain |
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Tags:
Oxidative Phosphorylation | |
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| 20 |
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Q:
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Which of the following would be expected in a population of eukaryotic cells under low-oxygen stress? |
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A
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increase in presence of oxidative radicals |
B
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a higher pH in the mitochondrial intermembrane space |
C
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decrease in fermentation processes |
D
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upregulation of the Krebs cycle |
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Tags:
Oxidative Phosphorylation | Eukaryotic Cells | |
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| 21 |
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Q:
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Which of the following holds false for the electron transport chain (ETC)? |
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A
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A proton gradient allows for generation of ATP. |
B
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In the last step of the chain, oxygen accepts a pair of electrons to form water. |
C
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Core proteins of the chain are housed on the inner mitochondrial membrane. |
D
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NADH is a byproduct of the electron transport chain. |
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Tags:
Oxidative Phosphorylation | |
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| 22 |
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Q:
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Which of the following components of the electron transport chain would be expected to have the lowest ionization energy? |
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A
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Complex I |
B
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O2 |
C
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Complex III |
D
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Cytochrome c |
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Tags:
Oxidative Phosphorylation | |
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| 23 |
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Q:
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Which of the following is TRUE regarding oxidative phosphorylation and electron carriers? |
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A
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Electron carriers are phosphorylated before being oxidized
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B
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Phosphorylation drives electron carriers to lower and lower energy levels
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C
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While oxygen is oxidized, ATP is produced by the phosphorylation of ADP
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D
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Through the process of electron transfer, an electrochemical gradient is created, and this drives the phosphorylation of ATP from ADP
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Tags:
Oxidative Phosphorylation | |
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| 24 |
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Q:
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Which of the following correctly describes a situation when cells switch from respiration to fermentation? |
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A
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When pyruvate is no longer available
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B
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When electron acceptors are no longer available
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C
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When NADH and FADH2 are in low quantity
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D
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When the proton-motive force is decreasing
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Tags:
Glycolysis, Gluconeogenesis, PPP | Oxidative Phosphorylation | |
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| 25 |
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Q:
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The deamination of alanine produces a carbon compound which then enters the Citric Acid Cycle. What is the identity of this carbon compound? |
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A
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Succinate |
B
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Acetyl-CoA
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C
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Malate |
D
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Fumarate |
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Tags:
Citric Acid Cycle | Oxidative Phosphorylation | |
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| 27 |
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Q:
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Which of the following is NOT correct regarding the maximum number of ATPs produced per molecule of aerobically oxidized glucose?
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A
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NADH influences the maximum number of ATPs since it cannot cross the inner mitochondrial membrane.
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B
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The maximum number of ATPs does not depend on the "shuttle system" used. |
C
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Using the malate shuttle to translocate electrons produced by glycolysis for oxidative phosphorylation results in 2.5 ATP per NADH.
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D
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Using the glycerol 3-phosphate shuttle to translocate electrons produced by glycolysis for oxidative phosphorylation results in 1.5 ATP per NADH. |
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Tags:
Glycolysis, Gluconeogenesis, PPP | Oxidative Phosphorylation | |
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| 28 |
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Q:
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Which of the following is true regarding the production of electron carriers during beta oxidation? |
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A
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Only NADH is formed during beta oxidation.
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B
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Only FADH2 is formed during beta oxidation.
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C
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Both NADH and FADH2 are formed during beta oxidation.
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D
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Neither NADH or FADH2 is formed during beta oxidation.
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Tags:
Metabolism of Fatty Acids and Proteins | Oxidative Phosphorylation | |
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| 29 |
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Q:
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The proteins responsible for the conversion of NADH to NAD+ as part oxidative phosphorylation are found at the: |
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A
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nuclear membrane. |
B
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cytosol. |
C
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outer membrane of the mitochondria. |
D
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inner membrane of the mitochondria. |
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Tags:
Oxidative Phosphorylation | |
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| 30 |
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Q:
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ATP synthase functions to make ATP via the movement of protons down an electrochemical gradient. This can be referred to as: |
|
A
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chemiosmotic coupling. |
B
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substrate level phosphorylation. |
C
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redox electrochemical phosphorylation. |
D
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active transport energy production. |
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Tags:
Oxidative Phosphorylation | |
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| 31 |
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Q:
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Which of the following is false regarding the electron transport chain? |
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A
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it is a component of oxidative phosphorylation. |
B
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it lives on the outer mitochondrial membrane. |
C
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it is crucial for ATP production within eukaryotic cells. |
D
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it functionally oxidizes the electron carriers NADH and FADH2 |
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Tags:
Eukaryotic Cells | Oxidative Phosphorylation | |
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| 32 |
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Q:
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Which of the following serves as the terminal electron acceptor in oxidative phosphorlyation? |
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A
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NAD+ |
B
|
NADH |
C
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Oxygen |
D
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CO2 |
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Tags:
Oxidative Phosphorylation | |
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| 33 |
Go |
Q:
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Which of the following elements involved in the electron transport chain have the lowest electron affinity? |
|
A
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NAD+ |
B
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NADH |
C
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cytochrome c |
D
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oxygen |
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Tags:
Oxidative Phosphorylation | |
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